Age-related neurodegenerative diseases—including Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia—are traditionally viewed through pathogenic mechanisms such as protein aggregation, mitochondrial dysfunction, and chronic inflammation. An equally important but less explored dimension is neuronal resilience: the factors that enable certain neurons to resist or delay degeneration despite similar pathological exposure. This session will bring together experts […] Read More
The menopausal transition represents a critical period of neuroendocrine change with important implications for brain health and neurological disease. Declines in estrogen during perimenopause and menopause are associated with changes in cognition, mood, and disease risk, yet the role of menopausal hormone therapy (MHT) in preserving brain health remains controversial. Use of MHT declined following […] Read More
More than 50% of the human genome consists of repetitive DNA, including micro- and macrosatellite repeats that contribute to a range of neurological diseases. This session will highlight recent advances in the biology of repeat expansion disorders, with a focus on somatic repeat instability as a key driver of disease and a potential therapeutic target. […] Read More
