Scott Zamvil, MD, PhD, FAAN, FANA
University of California, San Francisco
Scott S. Zamvil, MD, PhD, FAAN, FANA, is professor of neurology and faculty in the Program in Immunology at the University of California, San Francisco. Dr. Zamvil specializes in care of patients with multiple sclerosis (MS), neuromyelitis optica (NMO) and MOG antibody-associated disease (MOGAD). His research is devoted to understanding how autoantigens are recognized by T cells and how MS therapies modulate T cell activation. Using the MS model, EAE, Dr. Zamvil demonstrated for the first time that autoantigen-specific T cell clones can cause autoimmunity and his group discovered many of the T cell epitopes of CNS antigens in MS, NMO and MOGAD and their corresponding animal models. He has contributed to understanding the mechanism of immune modulation of several established and novel therapeutics, including glatiramer acetate (Copaxone®), anti-CD20 B cell depletion, dimethyl fumarate, cholesterol-lowering statins, anti-IL-6 receptor agents and CAR-T cells.