Blood-brain Barrier: From Basic Mechanisms to Therapeutics*
Date: October 19, 2026
Time: 12:00 pm to 1:00 pm
Room: Coral 2
Track: Interactive Lunch Workshop (ILW)
Session Description
This session will review the structure and function of the neurovascular unit in health and disease, with a focus on the blood–brain barrier (BBB). Faculty will highlight state-of-the-art techniques for in vivo BBB assessment and discuss their applications in advancing understanding of central nervous system disorders and therapeutic development.
Learning Objectives
At the conclusion of this session, attendees will be able to:
- Describe the structure and function of the blood–brain barrier and its role in brain health and disease.
- Compare key imaging modalities for BBB assessment, including dynamic susceptibility contrast (DSC) MRI and dynamic contrast-enhanced (DCE) MRI.
- Illustrate how BBB imaging can inform the pathophysiology and management of central nervous system disorders.
Speakers
Regional DCE-MRI Mapping of Vascular Integrity and BBB Permeability in Health and Neurological Disorder
Description
In this presentation, Dr. Friedman will explain how DCE-MRI enables assessment of vascular health including BBB permeability, revealing regional differences in controls and neurological disorders.
Imaging the Blood-Brain Barrier: A Window into Diseases of the Central Nervous System
Description
In this presentation, Dr. Leigh will discuss methods for imaging the Blood-brain Barrier (BBB) within the context of disease states that affect the BBB.
From Black Bags to Black Boxes: AI Assisted Clinical Diagnosis in Neurology
Description
In this presentation, Dr. Southerland will review several ways in which AI may be used to augment clinical diagnosis and reasoning in the practice of neurology.